Nursing Salary in South Carolina (2026 Guide)

Nursing Salary Overview in South Carolina

Estimated Nursing salary in South Carolina: $1,100–$1,700/week ($57,400–$88,600/year). Based on recent Nursing job trends. Top earners in specialized roles like tanker or hazmat can exceed $100,000 per year.

Salary by Job Type

Pay varies significantly depending on whether you drive local, regional, or over-the-road routes in South Carolina.

• Local nurses: $45,000–$65,000/year — home daily, lower mileage pay
• Regional nurses: $55,000–$75,000/year — multi-state routes, weekly home time
• OTR nurses: $60,000–$85,000/year — nationwide routes, highest mileage pay
• Owner-operators: $80,000–$150,000+/year — higher earnings but cover own expenses

Factors That Affect Nursing Pay

Several factors influence how much you can earn as a nurses in South Carolina.

• Years of experience — new drivers typically start 15–20% below average
• Nursing endorsements (hazmat, tanker, doubles/triples) can add $5,000–$15,000/year
• Route type and distance — OTR generally pays more than local
• Company vs. independent — owner-operators earn more but have higher expenses
• Freight type — specialized loads like refrigerated or oversized pay premiums